While LCS remodeling is clearly important for systemic calcium mobilization, this process may have additional potential drivers and may impact the ability of bone to resist fracture. The goal of this review is to examine the purpose and nature of LCS remodeling and its impacts on multiscale bone quality. The uncertainty in naming this physiological process reflects the many persistent questions about why and how osteocytes interact with local bone matrix. The existence of this phenomenon is now widely accepted, but is referred to as “osteocyte osteolysis,” “LCS remodeling,” and “perilacunar remodeling,” among other names. Osteocytes directly modify the bone surrounding the expansive lacunar-canalicular system (LCS) through both resorption and deposition. With osteocyte apoptosis potentially being a consequence of low mechanical stimuli, the early loss of osteocytes without initiation of bone remodelling indicates an adaptive response conserving the architecture of the auditory ossicles and ensuring stable sound transmission throughout life. The majority of these changes took place in the first months and years of life, while afterwards only minor reorganization was present. We detected characteristics of early bone tissue aging, such as decrease in osteocytes, lower total lacunar density and lacunar area, as well as high matrix mineralization accompanied by distinct accumulation of micropetrotic lacunae and decreased indentation depths. No signs of bone remodelling were observed above the age of 1 year. Mineralization of the bone matrix was determined using backscattered electron imaging. Here we analysed the frequency, size and composition of osteocyte lacunae in the auditory ossicles of 22 individuals from early postnatal period to old age. In human auditory ossicles, the early decrease in osteocyte numbers but maintained integrity remains an unexplained phenomenon that might serve for sound transmission from air to the labyrinth. ![]() ![]() A preserved osteocyte population is a crucial determinant of bone quality. Within the mineralized bone, osteocytes form a multifunctional mechanosensitive network orchestrating bone remodelling.
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